Genetic and Structural Analysis of Merkel Cell Polyomavirus Large T Antigen from Diverse Biological Samples
نویسندگان
چکیده
منابع مشابه
Genetic and structural analysis of Merkel cell polyomavirus large T antigen from diverse biological samples.
Merkel cell polyomavirus (MCPyV) large T antigen (LT-ag) is frequently found truncated in Merkel cell carcinomas (MCC) and it is considered a major tumor-specific signature. Nonetheless, the biological role of LT-ag nontruncated mutations is largely unknown. In this study, MCPyV LT-ag second exon from 11 non-MCC oral samples and NCBI sequences derived from different anatomical sites were studie...
متن کاملPhosphorylation of Large T Antigen Regulates Merkel Cell Polyomavirus Replication
Merkel Cell Polyomavirus (MCPyV) was recently discovered as a novel human polyomavirus that is associated with ~80% of Merkel Cell Carcinomas. The Large Tumor antigen (LT) is an early viral protein which has a variety of functions, including manipulation of the cell cycle and initiating viral DNA replication. Phosphorylation plays a critical regulatory role for polyomavirus LT proteins, but no ...
متن کاملMerkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma.
PURPOSE Merkel cell carcinoma (MCC) is rare skin cancer that is often associated with Merkel cell polyomavirus (MCPyV) infection. Polyomaviruses repress tumor suppressor proteins, thus influencing cell-cycle progression, but the effect of MCPyV on the key cell-cycle regulating proteins is poorly understood. EXPERIMENTAL DESIGN We evaluated expression of the MCPyV large T-antigen (LTA), Ki-67,...
متن کاملSignificant overexpression of the Merkel cell polyomavirus (MCPyV) large T antigen in Merkel cell carcinoma.
BACKGROUND The purpose of this study was to determine the expression pattern of the Merkel cell polyomavirus (MCPyV) large T-protein antigen in patients with Merkel cell carcinoma. METHODS A tissue microarray (TMA) containing 30 specimens was constructed and stained for the MCPyV large T protein. Immunohistochemical expression was determined semiquantitively and was compared to patients' outc...
متن کاملLarge T and small T antigens of Merkel cell polyomavirus.
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural component of skin flora, MCV becomes tumorigenic only after integration into the host DNA together with specific mutations to the viral genome. Research on MCV large T (LT) and small T (sT) antigens, the only viral products expressed in MCC, shows that th...
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ژورنال
عنوان ژورنال: Intervirology
سال: 2014
ISSN: 0300-5526,1423-0100
DOI: 10.1159/000363241